Benign prostate hyperplasia (BPH) was linked with metabolic syndrome in a large cohort of men from the UK, researchers found. “To our knowledge, this is the largest study to examine the prevalence of metabolic syndrome in a representative sample of men in the UK with and without BPH”.
According to lead author Dr. Julia R. DiBello, epidemiologist at GlaxoSmithKline in Collegeville, Pennsylvania, those with clinical BPH had higher odds of having the metabolic syndrome and each if its individual components, compared with matched controls without BPH.
While prior studies have already reported on this, it was important to do this study to see if the association was present in the UK in a general practice representative of the UK population. Men with clinical BPH have substantially greater odds of also having metabolic syndrome and should be appropriately screened, monitored, and treated.
Dr. DiBello and colleagues studied 85,103 men with clinical BPH and 85,103 men without it, matched by general practice, year of birth, and number of prior years of available history.
The researchers calculated the prevalence of the metabolic syndrome and its components for men alive and still registered in their database using all available prior history (lifetime prevalence) and prior medical history over roughly two years (current prevalence).
Overall, 26.5% of men with clinical BPH had the metabolic syndrome compared with 20.9% of matched controls (p<0.001), according to an article online September 22 in BJU International.
Compared to controls, significantly more men with clinical BPH also had each component of the metabolic syndrome.
For men with BPH, the odds of having the metabolic syndrome for both lifetime and current prevalence was 37% higher than for controls.
One key aspect of this study is the large cohort of more than 170,000 men. While there is no dramatic new finding in this study, the fact that the cohort is so large solidifies prior work published about the correlation between BPH and the metabolic syndrome. This study may allow clinicians to consider further investigations into the disease processes of diabetes, obesity, and cardiac disease in men with BPH.
The key question remains, ¿What is the common link? The discussion postulates that there may be associations between BPH and the metabolic syndrome through low serum testosterone levels, alpha adrenergic pathways, hyperinsulinemia, and nitric oxide pathways, to name a few. Only time and further investigation will allow us to determine the contributions of each factor to this unknown association.
SOURCE: BJU Int 2015. DOI: 10.1111/bju.13334 http://bit.ly/1VQoGdz