Using apheresis to remove a serum protein called soluble Fms-like tyrosine kinase-1 (Sflt-1) may help pregnant women with severe preeclampsia safely delay delivery, according to a pilot study published online September 24 in the Journal of the American Society of Nephrology.
In a randomized trial, spironolactone was the winner. Spironolactone was the clear “winner” in this valuable study of resistant hypertension; the inverse relation with baseline PRA suggests that its efficacy is related, at least in part, to enhanced natriuresis.
The addition of spironolactone to patients with resistant hypertension currently treated with renin-angiotensin-aldosterone system (RAAS) blockers, calcium-channel blockers (CCBs), and a thiazidelike diuretic resulted in a significant reduction in systolic blood pressure, according to the results of a new study.
Combining two diuretics, amiloride and hydrochlorothiazide (HCTZ), results in a significant reduction in blood pressure, more so than when each drug is used alone, and has the beneficial effect of neutralizing undesirable changes in blood glucose and potassium, according to the results of a new study.